A family of cell surface heparan sulphate proteoglycans (the glypican-related integral membrane proteoglycans, GRIPS) in which the core protein (500–600 aa) is GPI-anchored. Glypican-1 and glypican-4 are low-affinity receptors for endostatin. Glypican-3 appears to form a complex with insulin-like growth factor-2 and is implicated in growth control of mesodermal tissues during embryogenesis. Deletions and translocations involving the glypican-3 gene have been identified in patients with Simpson–Golabi–Behmel syndrome and the glypican-3 gene is frequently upregulated in hepatocellular carcinoma. Glypican-5 is reported to be amplified in rhabdomyosarcomas and glypican-6 has been identified.
Subjects: Chemistry — Medicine and Health.