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'glypican' can also refer to...



Glypicans in growth control and cancer

P-026Regulation of Glypican-3 by New MicroRNAs and Implication in Hepatocellular Carcinoma

Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway

Glypican (heparan sulfate proteoglycan) is palmitoylated, deglycanated and reglycanated during recycling in skin fibroblasts

Rapid nuclear transit and impaired degradation of amyloid β and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts

The Effect of Fibroblast Growth Factor 2 on the In Vitro Expression of Syndecan-4 and Glypican-1 in Turkey Satellite Cells1

Effect of glypican-1 covalently attached chains on turkey myogenic satellite cell proliferation, differentiation, and fibroblast growth factor 2 responsiveness 1

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

Copy number variation analysis implicates the cell polarity gene glypican 5 as a human spina bifida candidate gene

A novel role for nitric oxide in the endogenous degradation of heparan sulfate during recycling of glypican-1 in vascular endothelial cells

Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products

Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann–Pick C1 fibroblasts

Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes

The heparan sulfate–specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1

Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage

Molecular basis of differential target regulation by miR-96 and miR-182: the Glypican-3 as a model

1151PPhase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors


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A family of cell surface heparan sulphate proteoglycans (the glypican-related integral membrane proteoglycans, GRIPS) in which the core protein (500–600 aa) is GPI-anchored. Glypican-1 and glypican-4 are low-affinity receptors for endostatin. Glypican-3 appears to form a complex with insulin-like growth factor-2 and is implicated in growth control of mesodermal tissues during embryogenesis. Deletions and translocations involving the glypican-3 gene have been identified in patients with Simpson–Golabi–Behmel syndrome and the glypican-3 gene is frequently upregulated in hepatocellular carcinoma. Glypican-5 is reported to be amplified in rhabdomyosarcomas and glypican-6 has been identified.

Subjects: Chemistry — Medicine and Health.

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