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'GM-CSF' can also refer to...






240. GM-CSF Relative to IFNγ Release is Higher in Patients with PSA, and GM-CSF is Antagonistically Regulated By IL-23

Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer patients

Kinetic study of porcine GM-CSF expression in porcine alveolar macrophages and spleen cells

The effect of GM-CSF on development and aneuploidy in murine blastocysts

GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus


GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements

Cold Shock Domain Proteins Repress Transcription from the GM-CSF Promoter

Determinants of a transcriptionally competent environment at the GM-CSF promoter

Effect of Human Granulocyte-Macrophage Colony Stimulating Factor (hGM-CSF) on Lymphoid and Myeloid Differentiation of Sorted Hematopoietic Stem Cells from hGM-CSF Receptor Gene Transgenic Mice

GM-CSF with biochemotherapy (cisplatin, DTIC, tamoxifen, IL-2 and interferon-alpha): A phase I trial in melanoma

Effects of caspofungin, Candida albicans and Aspergillus fumigatus on toll-like receptor 9 of GM-CSF-stimulated PMNs

GM-CSF-mediated T-cell activation by macrophages infected with recombinant BCG that secretes major membrane protein-II of Mycobacterium leprae

Dose-intensive chemotherapy with doxorubicin, cyclophosphamide and GM-CSF fails to improve survival of metastatic breast cancer patients


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A cytokine (granulocyte-macrophage colony stimulating factor, CSF2, 127 aa, glycosylated) that stimulates the formation of granulocyte or macrophage colonies from myeloid stem cells and is secreted by activated macrophages and T-cells and secretion can be induced from endothelial cells and fibroblasts. It can also be expressed as an integral membrane protein. Recombinant protein has been expressed in yeast (and called sargramostim or molgramostim) and used clinically to stimulate bone marrow regeneration after transplantation or chemotherapy (TNs Leukine, Leukomax, Prokine). There are two receptors, a low-affinity one, CSF2Rα (400 aa) and a higher-affinity one (CSF2Rβ, 889 aa) that is also the high-affinity subunit for the IL-5 receptor (IL-5Rβ). A soluble form of the low-affinity receptor is also found.

Subjects: Medicine and Health.

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