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gossypol


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An aromatic amine derivative of cottonseed oil. It is toxic and reduces sperm counts to levels that are usually sufficient to impair fertility. It has been used since the 1920s by the Chinese as a male oral contraceptive. However, clinical trials in China in the 1980s of its safety and relative efficacy have shown that some users experience irreversible sterility, and a small proportion experience toxic nephritis. Its use has been discouraged in Western industrial nations.

Subjects: Medicine and Health — Chemistry.


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