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An acute metabolic arthritis, most frequently in the joints of the large toe, caused by the accumulation of monosodium urate crytals that induce inflammation. May arise from overproduction or underexcretion of uric acid. Usually treated with allopurinol, although classically colchicine was used, probably acting by inhibiting lysosome-phagosome fusion.

Subjects: Medicine and Health.

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