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An HIV envelope glycoprotein (41 kDa, 861 aa), encoded by the env gene, that promotes fusion of the virus with the plasma membrane of the host cells and is essential for infectivity. It is noncovalently bound to gp120, another envelope glycoprotein. The ectodomain has an N-terminal fusion domain that is highly hydrophobic, a membrane-spanning domain, and an endomain with a Tyr-based motif that interacts with the AP-2 clathrin adaptor protein.
From: gp41 in A Dictionary of Biomedicine »
Subjects: Medicine and Health.
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