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grammotoxin


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A peptide toxin (ω-grammotoxin, 36 aa), from the Chilean rose tarantula Grammostola spatulata, that inhibits P/Q and N-type voltage-gated calcium channels by binding at a site associated with channel gating, not the binding region of pore blockers such as ω-*conotoxins and ω-*agatoxin-IIIA. It also binds to potassium channels with lower affinity.

Subjects: Medicine and Health.


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