growth/differentiation factors

'growth/differentiation factors' can also refer to...

growth/differentiation factors

Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands

Fibroblast growth factor receptor expression reflects cellular differentiation in human oral squamous carcinoma cell lines.

The novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction

Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction

Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction

Growth differentiation factor-15 and cardiovascular dysfunction and disease: malefactor or innocent bystander?

Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy

Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain

Growth-differentiation factor-15 for risk stratification in patients with acute chest pain

Growth-differentiation factor-15 for risk stratification in patients with acute chest pain: reply

Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma

Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies

Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1)

Transforming growth factor-β-regulated miR-24 promotes skeletal muscle differentiation

245 Prognostic utility of growth-differentiation factor-15 in patients with chronic heart failure

Effect of Smad3-Mediated Transforming Growth Factor-β1 Signaling on Satellite Cell Proliferation and Differentiation in Chickens1

Midkine, a Heparin-Binding Growth/Differentiation Factor, Exhibits Nerve Cell Adhesion and Guidance Activity for Neurite Outgrowth In Vitro

CCN Family 2/Connective Tissue Growth Factor Modulates BMP Signalling as a Signal Conductor, Which Action Regulates the Proliferation and Differentiation of Chondrocytes


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A subfamily of the TGFβ superfamily, involved in growth and differentiation (Gdfs). Gdf1 (372 aa) acts early in the pathway of gene activation that leads to the establishment of left-right asymmetry and mutations are associated with congenital heart defects such as transposition of the great arteries and the tetralogy of Fallot. Gdf2 (429 aa) is bone morphogenetic protein (BMP)-9 which may be a differentiation factor for cholinergic central nervous system neurons. Gdf3 (364 aa) has been implicated in testis carcinoma and deposition of adipose tissue. Gdf4 is unreported. Gdf5 (BMP-14; cartilage-derived morphogenetic protein-1, 501 aa) is important in bone repair; Gdf6 (455 aa) is BMP13; Gdf7 (450 aa) is BMP12;. In mice Gdf5, Gdf6, and Gdf7 are all required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Gdf8 (375 aa) is myostatin. Gdf9 (454 aa) plays an important role in somatic cell differentiation and the formation of primordial follicles in hamster ovary. Gdf10 (478 aa) is BMP3B, closely related to BMP3 but with different tissue distribution. Gdf11 (407 aa) is BMP11, important in anterior/posterior patterning of the axial skeleton. The next reported Gdf of the series is Gdf15 (308 aa), macrophage inhibitory cytokine-1 (MIC-1).

Subjects: Medicine and Health.

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