Overview

GTP-binding protein


'GTP-binding protein' can also refer to...

GTP-binding proteins

GTP‐binding protein

Mutational analysis of Era, an essential GTP-binding protein of Escherichia coli

Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii

45-KDa GTP-binding Protein from Rat Olfactory Epithelium: Purification, Characterization and Localization

Functional study on GTP hydrolysis by the GTP-binding protein from Sulfolobus solfataricus, a member of the HflX family

Altering the GTP binding site of the DNA/RNA-binding protein, Translin/TB-RBP, decreases RNA binding and may create a dominant negative phenotype

The actin-based motility of intracellular Listeria monocytogenes is not controlled by small GTP-binding proteins of the Rho- and Ras-subfamilies

Deletion of the putative effector region of Era, an essential GTP-binding protein in Escherichia coli, causes a dominant-negative phenotype

Purification and Functional Reconstitution with GTP-Binding Regulatory Proteins of Hexahistidine-Tagged Muscarinic Acetyicholine Receptors (m2 Subtype)

Activities of Mutant Sar1 Proteins in Guanine Nucleotide Binding, GTP Hydrolysis, and Cell-Free Transport from the Endoplasmic Reticulum to the Golgi Apparatus

A Novel Pseudoautosomal Gene Encoding a Putative GTP-Binding Protein Resides in the Vicinity of the Xp/Yp Telomere

Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity

The Role of GTP Binding and Microtubule-Associated Proteins in the Inhibition of Microtubule Assembly by Carbendazim

Formation of the Functional Complexes of m2 Muscarinic Acetylcholine Receptors with GTP-Binding Regulatory Proteins in Solution

A novel antibacterial agent derived from the C-terminal domain of Streptococcus mutans GTP-binding protein

Identification of a 42-kDa Group IV cPLA2-activating protein, cPLAPγ, as a GTP-binding protein in the bovine brain

Small GTP-binding proteins of the Rho- and Ras-subfamilies are not involved in the actin rearrangements induced by attaching and effacing Escherichia coli

P5164Protective roles of small GTP-binding protein GDP dissociation stimulator against angiotensin II-induced thoracic aortic aneurysm formation and rupture in mice -A possible novel therapeutic target-

 

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Although many proteins bind GTP (e.g. actin, tubulin) the GTP-binding proteins are considered special cases because of their role in signalling. There are two classes of these G proteins: heterotrimeric G proteins that associate with G-protein-coupled receptors, and the small cytoplasmic G proteins. The heterotrimeric G proteins have a Gα subunit (39–52 kDa) with slow GTP-ase activity: when GTP binds the α subunit dissociates from the βγ subunits (β, 35–36 kDa: γ, 6–10 kDa) and is able to interact with various second messenger systems, either inhibiting (Gi), stimulating (Gs), or otherwise (Go). Once the GTP is hydrolysed the heterotrimer re-forms and activation ceases. The βγ subunits, most of which are membrane associated through post-translational myristoylation or isoprenylation, may have direct activating effects in their own right, though they are less diverse than the α subunits. Stimulatory G proteins (Gαs-βγ) are permanently activated by cholera toxin, inhibitory ones (Gαi-βγ) by pertussis toxin. Transducin (Gαt-βγ) was one of the first of the heterotrimeric G proteins to be identified. The small G proteins are a diverse group of monomeric GTPases that include ras, rab, rac, and rho and play an important part in regulating many intracellular processes including cytoskeletal organization and secretion. Their GTPase activity is regulated by activators (GTPase-activating protein, GAPs) and inhibitors (GIPs) that determine the duration of the active (GTP-bound) state. See also GEFs; ras-like GTPases.

Subjects: Medicine and Health.


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