guanylate cyclase

'guanylate cyclase' can also refer to...

guanylate cyclase

guanylate cyclase

guanylate cyclase

guanylate cyclase

guanylate cyclase

Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension

Arg–Gly–Asp (RGD)-containing peptides increase soluble guanylate cyclase in contractile cells

P508Pharmacological activation of the soluble guanylate cyclase inhibits pressure overload-induced cardiac hypertrophy

Tirofiban increases soluble guanylate cyclase in rat vascular walls: pharmacological and pathophysiological consequences

Mutations in the Retinal Guanylate Cyclase (RETGC-1) Gene in Dominant Cone-Rod Dystrophy

468 Additional particulate guanylate cyclase activation with BNP does not augment the hemodynamic actions of the direct soluble guanylate cyclase activator BAY 58-2667 but it enhances renal function

Soluble guanylate cyclase (sGC) down-regulation by abnormal extracellular matrix proteins as a novel mechanism in vascular dysfunction: Implications in metabolic syndrome

Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase

Purification of Bovine Soluble Guanylate Cyclase and ADP-Ribosylation on its Small Subunit by Bacterial Toxins

Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia–reperfusion injury after cardiopulmonary bypass

Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes†

Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure†

RD3 gene delivery restores guanylate cyclase localization and rescues photoreceptors in the Rd3 mouse model of Leber congenital amaurosis 12

Functional characterization of missense mutations at codon 838 in retinal guanylate cyclase correlates with disease severity in patients with autosomal dominant cone–rod dystrophy


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A heterodimeric protein (with α and β subunits) that catalyses the synthesis of the second messenger guanosine 3′,5′- cyclic monophosphate (cGMP) from GTP. The enzyme is the main receptor for nitric oxide (NO) and nitrovasodilator drugs which stimulate the production of cGMP. The soluble form is found in brain and has α1 (690 aa) and β1 (619 aa) subunits. The plasma membrane form of guanylate cyclase is an integral membrane protein with an extracellular receptor for peptide hormones, a transmembrane domain, a protein kinase-like domain, and a guanylate cyclase domain. Various isoforms are known, some being receptors for natriuretic peptides. Mutations in human photoreceptor guanylate cyclase 2D (1103 aa) cause some forms of Leber congenital amaurosis and a dominant form of cone–rod dystrophy. Guanylate cyclase-activating protein (GCAP1, 201 aa) is a calcium-binding protein of the calmodulin superfamily, expressed exclusively in photoreceptor inner segments, that stimulates synthesis of cGMP. Mutations in this cause cone dystrophy and may be responsible for other types of Leber amaurosis. Guanylin is GCAP2A, uroguanylin is GCAP2B.

Subjects: Medicine and Health — Chemistry.

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