A method of reconstructive periodontal treatment aimed at providing conditions which aid the ingrowth of cells from the periodontal ligament to form a new attachment, while excluding those from the oral epithelium and the gingival connective tissue. An artificial membrane is placed between the cleaned root surface and the overlying soft tissue flap. Initially non-resorbable membranes made of cellulose acetate (trade name Millepore®) or expanded polytetrafluoroethylene (e-PTFE; trade name Gore-Tex®) were used; these have been superseded by porcine collagen (trade name: Bio-Gide®) and synthetic resorbable membranes such as polyglactin/polylactide (trade name: Vicryl®), which have the advantages of reduced surgical time, less risk of damage to regenerated tissues, and better biocompatibility. Guided bone regeneration describes alveolar ridge augmentation or bone regeneration procedures.
Needleman I., Tucker R., Giedrys-Leeper E., Worthington H. Guided tissue regeneration for periodontal intrabony defects – a Cochrane Systematic Review. Periodontol 2005;37:106–23.