haematopoietic cell kinase

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A protein tyrosine kinase (hck, haemopoietic cell kinase, 526 aa) of the src family found in lymphoid and myeloid cells and that is bound to B-cell receptors in unstimulated B cells. The hck gene is located in a region affected by interstitial deletions in some acute myeloid leukaemias and myeloproliferative disorders. The catalytic activity of hck is regulated, both positively and negatively, by tyrosine phosphorylation: phosphorylation of the Tyr499 residue in the COOH terminus of hck by the protein kinase Csk inactivates hck, whereas autophosphorylation of Tyr388 within the kinase domain upregulates kinase activity.

Subjects: Medicine and Health.

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