hairpin ribozyme

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'hairpin ribozyme' can also refer to...

hairpin ribozyme

hairpin ribozyme

Functional Domain-Assembly in Hairpin Ribozymes

Intracellular RNA cleavage by the hairpin ribozyme

Comparative analysis of hairpin ribozyme structures and interference data

The catalytic mechanism of hairpin ribozyme studied by hydrostatic pressure

Sensing complex regulatory networks by conformationally controlled hairpin ribozymes

RNA double cleavage by a hairpin-derived twin ribozyme

Hairpin ribozyme-antisense RNA constructs can act as molecular lassos

Metal Ions Play a Passive Role in the Hairpin Ribozyme Catalysed Reaction

The Loop B Domain Is Physically Separable from the Loop A Domain in the Hairpin Ribozyme

Modification and Application of Self-Trimming Hairpin Ribozymes to Targeting a Transcribed RNA In Vitro

In Vitro Activity of the Hairpin Ribozyme Derived from the Negative Strand of Arabis Mosaic Virus Satellite RNA

Chemical syntheses of inhibitory substrates of the RNA–RNA ligation reaction catalyzed by the hairpin ribozyme

Base and Sugar Requirements for RNA Cleavage of Essential Nucleoside Residues in Internal Loop B of the Hairpin Ribozyme: Implications for Secondary Structure

Investigation of the recognition of an important uridine in an internal loop of a hairpin ribozyme prepared using post-synthetically modified oligonucleotides

Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions

Evolutionary optimization of a modular ligase ribozyme: a small catalytic unit and a hairpin motif masking an element that could form an inactive structure

Generation of circular RNAs and trans-cleaving catalytic RNAs by rolling transcription of circular DNA oligonucleotides encoding hairpin ribozymes


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The catalytic center of the 359-base, negative strand of the satellite RNA (q.v.) of the tobacco ringspot virus; it consists of a catalytic segment 50 bases long and a 14-base substrate. The catalytic RNA forms a closed loop during the cleavage reaction, hence the term hairpin ribozyme (HR). The HR has been engineered to bind to and cleave specific foreign RNAs. One of these is the transcript from a gene of the HIV-I virus that is essential for its replication. Suitably engineered ribozymes may someday play an important role in AIDS therapy. See AIDS, HIV, plus (+) and minus (−) viral strands, ribozyme.

Subjects: Genetics and Genomics.

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