Overview

HCV core protein


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One of 10 virally encoded proteins, a viral structural protein (hepatitis C core protein, 3010 aa) that affects multiple cellular processes, blocks the activity of caspase-activated DNase and thus inhibits apoptotic cell death. Maturation of core protein requires coordinate cleavage by signal peptidase and an intramembrane protease, signal peptide peptidase. An alternate reading frame (ARF) overlaps with the core protein-encoding sequence and encodes the ARF protein (ARFP).

Subjects: Medicine and Health.


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