heavy chain

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In general, the larger subunit of a multimeric protein. The immunoglobulin heavy chain is of 50 kDa, the light chain of 22 kDa, whereas in myosin the heavy chain is ~220 kDa and the light chain a mere 20 kDa. Heavy chain diseases are rare B-cell proliferative disorders characterized by the synthesis and secretion of aberrant immunoglobulin heavy chains. They can be subdivided according to the heavy chain type (μ, γ, etc.) and the extent to which the peptide is truncated or altered.

Subjects: Chemistry — Medicine and Health.

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