HECT domain

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A catalytic domain (homologous to E6-AP C-terminus, ~350 aa) found at the C-terminus of Hect-class E3 ubiquitin protein ligases. The domain binds specific E2 enzymes, accepts ubiquitin, and transfers it either directly to the substrate or to the growing end of multiubiquitin chains. See ubiquitin conjugating enzymes.

Subjects: Medicine and Health.

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