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A protein toxin (242 aa) stabilized by eight disulphide bridges, from the venom of the Mexican beaded lizard Heloderma horridum horridum, that inhibits the ryanodine receptor in skeletal and cardiac muscle. Has no homology with other channel-blocking toxins but appears to be a member of a family of cysteine-rich secretory proteins (CRISP) described in human and mouse testis.

Subjects: Medicine and Health.

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