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hemoglobin Bart's


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Hemoglobin made up of homotetramers of gamma globin chains. In alpha thalassemia, the underproduction of alpha globin chains stimulates the expression of gamma globin genes. As a result, gamma globin tetramers become predominant. In fetuses homozygous for deletions in alpha hemoglobin genes, the level of Bart's hemoglobin is 80%–100%, and hydrops fetalis (q.v.) results. The hemoglobin was identified at St. Bartholomew's Hospital in London. This venerable hospital, founded in 1123, is nicknamed “Bart's.” See hemoglobin fusion genes.

Subjects: Genetics and Genomics.


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