A hemoglobin with an abnormal beta chain. Lysine is substituted for glutamic acid at position 6. Hemoglobin C is thought to protect against malaria by interfering with the production of adhesion knobs on the surface of infected red blood cells. AC and CC erythrocytes show reduced adhesion to endothelial monolayers. Therefore parasitized cells are more likely to be swept into the spleen and destroyed. See hemoglobin S.
Subjects: Genetics and Genomics.