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hemoglobin Lepore


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An abnormal hemoglobin named after the Italian family in which it was first found. The protein contains a pair of normal alpha chains and a pair of abnormal chains, each chain made up of 146 amino acids. Each abnormal chain appears to be a hybrid molecule consisting of an N-terminal end containing amino acids in a sequence characteristic of the left end of the delta chain and a C-terminal end containing amino acids in a sequence characteristic of the right end of a beta chain. Hemoglobin Lepore is presumed to have arisen by unequal crossing over between a mispaired delta and beta cistron.

Subjects: Genetics and Genomics.


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