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A lysosomal endoglycosidase (HSE1, HPA, EC 3.2.1.-, 543 aa) that will cleave heparan sulphate into characteristic large molecular weight fragments. Heparanase apparently plays an important role in degrading extracellular matrix heparan sulphate to facilitate extravasation of tumour cells and leucocytes and, by degrading heparan sulphate, will alter the binding of various signalling molecules.

Subjects: Medicine and Health.

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