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'heparanase' can also refer to...


Glycosaminoglycans affect heparanase location in CHO cell lines

Heparanase Gene Silencing, Tumor Invasiveness, Angiogenesis, and Metastasis

Novel Heparanase-Inhibiting Antibody Reduces Neointima Formation

Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans

Overexpression of heparanase in mice promoted megakaryopoiesis

Heparanase procoagulant activity is elevated in women using oral contraceptives

Macrophage Polarization in Pancreatic Carcinoma: Role of Heparanase Enzyme

Heparanase expression in invasive trophoblasts and acute vascular damage

Localization of heparanase in normal and pathological human placenta

Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer

Involvement of Heparanase in Tumor Metastases: A New Target in Cancer Therapy?

Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization

Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus

Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium

Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase

Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts

The role of heparanase and the endothelial glycocalyx in the development of proteinuria

Urinary heparanase activity in patients with Type 1 and Type 2 diabetes


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A lysosomal endoglycosidase (HSE1, HPA, EC 3.2.1.-, 543 aa) that will cleave heparan sulphate into characteristic large molecular weight fragments. Heparanase apparently plays an important role in degrading extracellular matrix heparan sulphate to facilitate extravasation of tumour cells and leucocytes and, by degrading heparan sulphate, will alter the binding of various signalling molecules.

Subjects: Medicine and Health.

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