Overview

hepatocyte growth factor


'hepatocyte growth factor' can also refer to...

hepatocyte growth factor

hepatocyte growth factor

hepatocyte growth factor receptor

hepatocyte growth factor receptor

hepatocyte growth factor-like protein

Hepatocyte growth factor and Met in drug discovery

Emerging Multipotent Aspects of Hepatocyte Growth Factor

Unexpected effect of haemodialysis on salivary hepatocyte growth factor

Help from within: cardioprotective properties of hepatocyte growth factor

Stimulation of Hepatocyte Growth Factor Production by Heparin-derived Oligosaccharides

Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis

Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells

Elevation of Glutathione Level in Rat Hepatocytes by Hepatocytes by Hepatocyte Growth Factor viaInduction of γ-Glutamylcysteine Synthetase

CANCER BIOLOGY: Expression of transforming growth factor alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis

Role of transforming growth factor α and prostaglandins in preferential growth of preneoplastic rat hepatocytes

Novel hepatocyte growth factor/scatter factor isoform transcripts in the macaque endometrium and placenta

Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas

Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro

Effect of Hepatocyte Growth Factor/Scatter Factor on Lipogenesis in Adult Rat Hepatocytes in Primary Culture

 

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A mitogen for hepatocytes (HGF, scatter factor, hepatopoietin A, lung fibroblast-derived mitogen) derived, in the liver, from nonparenchymal cells. It is mitogenic for several cell types and is found in many cells outside the liver, including platelets. HGF is synthesized as a single chain precursor (728 aa) that is cleaved to a heavy chain (463 aa) and a light chain (234 aa) that remain disulphide-linked. Both the uncleaved precursor and the two-chain form of HGF are biologically active and HGF is generally isolated as a mixture of the two forms. HGF also alters cell motility and is identical to scatter factor. The HGF receptor gene, the met oncogene product, is on the same region of chromosome 7 (7q) as HGF itself so that polysomy of chromosome 7 can confer invasive and proliferative capacity through an autocrine effect, and polysomy of chromosome 7 is the most common abnormality in human malignant gliomas. Differentiation of pre-pro-B cells to pro-B cells requires signalling through the IL-7 receptor by IL-7 in association with the β chain of HGF and heparin sulphate. HGF-stimulation of hepatocytes through the MET receptor makes cells susceptible to infection by sporozoites of Plasmodium and damage caused by sporozoite migration causes release of HGF.

Subjects: Medicine and Health.


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