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HNF


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HNF

HNF

Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4α and HNF1β in a pancreatic β-cell line

Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors

Characterization of a Dominant Negative Mutant Form of the HNF-4 Orphan Receptor

Criteria for HNF1B analysis in patients with congenital abnormalities of kidney and urinary tract

Renal cysts and diabetes due to a heterozygous HNF-1β gene deletion

Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A

Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis

HNF1 β/TCF2 mutations impair transactivation potential through altered co-regulator recruitment

Characterization of the PC4 Binding Domain and its Interactions with HNF4α

SO056NOVEL MECHANISM OF GLOMERULAR CYST FORMATION IN HNF1B DEFICIENCY

The embryonic expression of the tissue-specific transcription factor HNF1α in Xenopus: Rapid activation by HNF4 and delayed induction by mesoderm inducers

Extinction of α1-antitrypsin expression in cell hybrids is independent of HNF1α and HNF4 and involves both promoter and internal DNA sequences

HNF1B-MODY: A Disorder of Development With Diabetes and Congenital Malformations in the Pancreas and Urogenital Tract Due to Mutations in HNF1B

An enhancer element 6 kb upstream of the mouse HNF4α1 promoter is activated by glucocorticoids and liver-enriched transcription factors

Proteomic screen defines the hepatocyte nuclear factor 1α-binding partners and identifies HMGB1 as a new cofactor of HNF1α

Comprehensive search for HNF‐1β‐regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor‐targeted RNAi

Comprehensive search for HNF-1β-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi

 

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A family of transcription factors (hepatocyte nuclear factors) enriched in liver. HNF1 is predominantly expressed in liver and kidney and selectively interacts with the control regions of several liver-specific genes. Heterozygous mutations in hepatocyte nuclear factor (HNF)-1α and HNF-1β result in maturity-onset diabetes of the young.

Subjects: Chemistry.


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