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A humanized monoclonal antibody that blocks EGF-mediated cell proliferation by binding to the epidermal growth factor receptor (HER2; c-erbB2). Only the subset of breast carcinomas (25–30%) that overexpress HER2 can be treated with this antibody, one of the first examples of the importance of pharmacogenomics. TN Trastuzumab.

Subjects: Medicine and Health.

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