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herstatin


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A secreted protein (419 aa) that is the product of an alternative ErbB2 transcript that retains intron 8 (see epidermal growth factor). Herstatin appears to be an inhibitor of p185-ErbB2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress ErbB2.

Subjects: Medicine and Health.


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