heterozygosity index

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A measure of the number of gene loci that are heterozygous; a completely inbred individual, homozygous at all loci, would have an index value of zero. It can be estimated for individuals or for populations. For example, the ApaLI polymorphism in intron 5 of the Wilms' tumour gene has a heterozygosity index of 24% in the USA but 59% in the Japanese population, with potential implications for the prevalence of the disorder.

Subjects: Medicine and Health.

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