H19 gene

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An imprinted, maternally expressed gene (adult skeletal muscle gene) that is tightly linked and coregulated with the imprinted, paternally expressed gene of insulin-like growth factor 2 (IGF2). Control of which allele is expressed is by the imprinting centre 1 (IC1). The product of H19 is an oncofetal RNA that is not translated and may be a tumour suppressor. Hypermethylation of H19 is associated with Beckwith–Wiedemann syndrome and hypomethylation of the H19 promoter with Silver–Russell syndrome.

Subjects: Medicine and Health.

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