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high endothelial venule


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(HEV)

A type of venule in which the endothelium, instead of being thin and squamous in morphology, is cuboidal. They are characteristic of lymph nodes where lymphocyte extravasation occurs in the normal trafficking. Morphologically similar endothelium is associated with some chronic inflammatory lesions. The adhesion molecules, GlyCAM-1 (MadCAM-1 in mucosal HEVs), ICAM-1, and CD34 expressed on the apical surfaces account for preferential lymphocyte adhesion through selectins and LFA-1.

Subjects: Medicine and Health.


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