high-mobility group proteins

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A set of nonhistone chromosomal proteins involved in a wide variety of cellular processes including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the induction of neoplastic transformation and metastatic progression. Contain conserved DNA-binding peptide motifs (AT hooks) that preferentially bind to the minor groove of many AT-rich promoter and enhancer DNA regulatory elements. Lack of HMGA1 (215 aa) is reported to cause insulin resistance and diabetes; HMGIY has been suggested as a potential oncogene. HMG2 (208 aa) is a component of the SET complex.

Subjects: Medicine and Health.

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