Hill coefficient

'Hill coefficient' can also refer to...


More Like This

Show all results sharing this subject:

  • Medicine and Health


Show Summary Details

Quick Reference

A coefficient devised by A. V. Hill (1886–1977) to describe the binding of oxygen to haemoglobin (Hill coefficient of 2.8) and used more generally as a measure of cooperativity in a binding process. A Hill coefficient of 1 indicates independent binding, a value greater than 1 indicates positive cooperativity in which binding of one ligand facilitates binding of subsequent ligands at other sites; a value less than 1 indicates negative cooperativity. It can be estimated graphically using a Hill plot of initial reaction velocity (or fractional binding saturation) against substrate concentration.

Subjects: Medicine and Health.

Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.