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Hirschsprung disease


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A congenital condition in which the rectum and sometimes part of the lower colon have failed to develop a normal nerve network. The affected portion does not expand or conduct the contents of the bowel, which accumulate in and distend the upper colon. Symptoms, which are usually apparent in the first weeks of life, are vomiting, constipation, abdominal distension, and intestinal obstruction. Diagnosis is by X-ray and by microscopic examination of samples of the bowel wall, which shows the absence of nerve cells. Treatment is by surgery to remove the affected segment and join the remaining (normal) colon to the anus. See also megacolon. H. Hirschsprung (1830–1916), Danish physician

Subjects: Medicine and Health.


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