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histidine triad


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A motif (HIT) related to the sequence H-ϕ-H-ϕ-H-ϕ-ϕ (where ϕ is a hydrophobic amino acid). Proteins containing HIT domains form a superfamily with nucleotide-binding and diadenosine polyphosphate hydrolase activities. Examples include aprataxin, and the GalT subfamily of nucleoside monophosphate transferases (e.g. galactose-1-phosphate uridylyltransferase) that bind zinc and iron. The fragile histidine triad (FHIT) gene encodes a protein (fragile histidine triad protein,147 aa) that has AP3A hydrolase (dinucleoside-triphosphatase, EC 3.6.1.29) activity and may be a tumour suppressor. Histidine triad nucleotide-binding protein 5 (337 aa) is an mRNA decapping enzyme.

Subjects: Medicine and Health.


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