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histocompatibility molecules


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MHC

 

'histocompatibility molecules' can also refer to...

histocompatibility molecules

histocompatibility molecules

Rhinovirus Infection Induces Major Histocompatibility Complex Class I and Costimulatory Molecule Upregulation on Respiratory Epithelial Cells

Levamisole Effects on Major Histocompatibility Complex and Adhesion Molecule Expression and on Myeloid Cell Adhesion to Human Colon Tumor Cell Lines

Structural comparison of major histocompatibility complex class I molecules and homology modelling of five distinct human leukocyte antigen-A alleles

Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity

Perspective: my 37 year journey through Chlamydia  research: Chlamydia  antigen analysis using monoclonal antibodies and major histocompatibility complex molecules

Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I–Related Molecule–Dependent and Cytokine-Driven Pathways

Virus-Specific Cytotoxic T Lymphocytes Differentially Express Cell-Surface Leukocyte Immunoglobulin-Like Receptor–1, an Inhibitory Receptor for Class I Major Histocompatibility Complex Molecules

Genetic Variants in Nonclassical Major Histocompatibility Complex Class I Human Leukocyte Antigen (HLA)–E and HLA-G Molecules Are Associated with Susceptibility to Heterosexual Acquisition of HIV-1

Expression of Major Histocompatibility Complex Class I Chain–Related Molecule A, NKG2D, and Transforming Growth Factor–β in the Liver of Humans with Alveolar Echinococcosis: New Actors in the Tolerance to Parasites?

 

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Genetically encoded cell-surface alloantigens that can cause the rejection of grafted tissues, cells, and tumors bearing them. These cell-membrane glycoproteins are grouped into two classes. Class I molecules are found on the surfaces of all mammalian cells (except trophoblasts and spermatozoa). T lymphocytes (q.v.) of the CD8+ subgroup recognize antigenic determinants of foreign class I histocompatibility molecules. Class II histocompatibility molecules are abundant on the surfaces of B lymphocytes (q.v.). T lymphocytes of the CD4+ subgroup recognize antigenic determinants of foreign class II histocompatibility molecules. These T cells subsequently divide and secrete lymphokines (q.v.), which are important for B cell growth and differentiation. Class I histocompatibility molecules are heterodimers made up of heavy (alpha) and light (beta) polypeptide chains. The class I chains are encoded by genes residing in the right portion of the HLA complex (q.v.). The alpha chain contains regions showing sequence diversity, whereas the beta chain has an invariant amino acid composition. The class II histocompatibility molecules are also dimers composed of heavy alpha and light beta chains. These are encoded by genes in the left portion of the HLA complex. Most of the sequence diversity of class II histocompatibility molecules is localized within a segment of the beta chain. Class II histocompatibility dimers are associated with a third polypeptide chain that exhibits no polymorphism. See Chronology, 1937, Gorer; 1987, Wiley et al.; major histocompatibility complex.

Subjects: Genetics and Genomics.


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