A family of eleven enzymes in humans (HDACs, EC 3.5.1.-) that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone, reversing the effect of histone acetyltransferases. Acetylation is thought to be increased in active genes, so deacetylation should switch off genes. Inhibitors of HDAC are being tested as antitumour drugs. The HDAC complex consists of HDAC1, HDAC2, and retinoblastoma-binding proteins 4 and 7 (RBBP4 and RBBP7) which promotes histone deacetylation and transcriptional repression.
Subjects: Medicine and Health — Chemistry.