Hofmann's reaction

Related Overviews


'Hofmann's reaction' can also refer to...


More Like This

Show all results sharing this subject:

  • Chemistry


Show Summary Details

Quick Reference

A reaction for making primary amines from amines using bromine or chlorine and sodium hydroxide:RCONH2 → RNH2 The halogen replaces a hydrogen atom from the amido group to form a halo-amide. This then reacts with the alkali to produce an isocyanate, which decomposes into the amine and carbon dioxide. The amine has one carbon atom fewer than the amide from which it is produced. This technique is used to reduce the length of carbon chains in molescules (the Hofmann degradation). The reaction is named after the German chemist August Wilhelm von Hofmann (1818–92).


Subjects: Chemistry.

Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.