homologous recombination

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The exchange or replacement of genetic material as a result of crossing over (q.v.) or gene conversion (q.v.), respectively. Homologous recombination occurs between two long stretches of DNA with similar sequences, which may be present in two homologous chromosomes, in non-homologous chromosomes, or within a chromosome. Meiotic and mitotic recombination (q.v.) are examples of homologous recombination. Compare with site-specific recombination. See Holliday model.

Subjects: Genetics and Genomics — Chemistry.

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