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The product (harakiri, death protein 5, 91 aa) of the apotosis-regulating gene harakiri, that interacts with the death-repressor proteins bcl-2 and bcl-XL, but not with death-promoting homologues, bax or bak. Has a short bcl-2 homology domain 3 (BH3 domain) but no BH1 or BH2 domains. Expression of hrk in mammalian cells induces rapid cell death, and hrk up-regulation is involved in gentamicin-induced ototoxicity.

Subjects: Medicine and Health.

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