A giant virus (240 nm in diameter) belonging to the Herpesviridae. Most of the congenital viral infections in humans are caused by this virus. The genome is a 230 kbp linear dsDNA in which reside at least 208 ORFs. HCMV is covered by a phospholipid envelope. Between this and the capsid is a compartment (the tegument) which contains 20 different proteins encoded by the viral genome. Four different mRNAs are packaged inside the virion. See Genome Sizes and Gene Numbers, virus.
Subjects: Genetics and Genomics.