Overview

human gene maps


'human gene maps' can also refer to...

The Human Gene Map

human gene maps

human gene maps

BodyMap: a human and mouse gene expression database

Eighteen Novel Human Genes Regionally Mapped on Chromosome 11

GeneLoc: exon-based integration of human genome maps

Visualization of individual DNA loops and a map of loop domains in the human dystrophin gene

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

Transcriptional regulation of human MAP2 gene in melanoma: role of neuronal bHLH factors and Notch1 signaling

The Gene for Schnyder's Crystalline Corneal Dystrophy Maps to Human Chromosome 1p34.1–p36

A Human Modifier of Methylation for Class I HLA Genes (Memo-1) Maps to Chromosomal Bands 1p35–36.1

The Human Magel2 Gene and Its Mouse Homologue Are Paternally Expressed and Mapped to the Prader-Willi Region

Physical Map of the Human Chromosome 8p12-p21 Encompassing Tumor Suppressor and Werner's Syndrome Gene Loci

Transcriptional regulation of human MAP2 gene in melanoma: role of neuronal bHLH factors and Notch1 signaling

Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines

Mouse Homologues of the Human AZF Candidate Gene RBM Are Expressed in Spermatogonia and Spermatids, and Map to a Y Chromosome Deletion Interval Associated with a High Incidence of Sperm Abnormalities

ACCELERATED PAPER: Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A(p16INK4A )

 

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The total human genome contains 3.2 Gbp of DNA, and 2.95 Gbp of this represents euchromatin (q.v.). There are about 31,000 genes that transcribe mRNAs and at least 750 genes that encode other RNAs. For example, there are about 500 different tRNA genes. The genes are distributed over 22 pairs of chromosomes that range in size from autosome 1 (263 Mbp) to autosome 21 (50 Mbp). The X and Y chromosomes are 164 and 59 Mbp, respectively. The most gene-rich chromosome is autosome 19 (with 23 genes/Mbp), while the least gene-rich chromosomes are autosome 13 and the Y (each with 5 genes/Mbp). Genes (or at least their coding regions) make up only 1–2% of the genome. Just over 40% of the genes that encode proteins have orthologs in Drosophila and Caenorhabditis. Hundreds of human genes have resulted by horizontal transfer from bacteria at some point during the evolution of vertebrates. More than half of the genome is composed of repetitious DNA (q.v.). About 45% of the genome is derived from transposable elements (q.v.). Although the human genome has only about twice as many protein-coding genes as Drosophila or Caenorhabditis, human genes are more complex and often undergo alternative splicing (q.v.) to produce an array of different transcripts. More than 1,000 genes that cause specific diseases when they mutate have been mapped and are listed in OMIM (q.v.). The human mitochondrial chromosome is sometimes referred to as chromosome 25 or M. See Chronology, 2001, Collins and Venter et al.; 2003, International Human Genome Sequencing Consortium; Down syndrome, gene, genome annotation, horizontal transmission, human mitochondrial DNA, repetitious DNA.

Subjects: Genetics and Genomics.


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