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human genome epidemiology


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(HuGE)

The intersection of genetics and epidemiology in studies of the distribution and genomic determinants of important diseases, e.g., diabetes and other disorders of metabolism, cancer, cardiovascular disease, osteoporosis, and schizophrenia. The aim is to identify genetic factors that could be manipulated by interventions to prevent or retard progress of conditions attributable to aberrations of the genome. It is the systematic application of epidemiologic methods and approaches to the human genome to assess the impact of human genetic variation on health and disease. The applications include (1) gene discovery; (2) population risk characterization; (3) evaluation of genetic information for diagnosis and prevention (including genetic tests and family history information, both for clinical use and for population screening) and for genome-based therapies. The Human Genome Epidemiology Network (HuGEnet) is a worldwide collaboration that is assessing how genomic variation affects population health. See http://www.cdc.gov/genomics/hugenet/default.htm.

(1) gene discovery; (2) population risk characterization; (3) evaluation of genetic information for diagnosis and prevention (including genetic tests and family history information, both for clinical use and for population screening) and for genome-based therapies.

Subjects: Public Health and Epidemiology.


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