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Hurthle cells


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Abnormal thyroid epithelial cells (Ashkenazy cells, oxyphil cells, oncocytes) found in Hashimoto's thyroiditis and follicular thyroid cancer. The cells are enlarged, have abundant eosinophilic granular cytoplasm and often have bizarre nuclear morphology. Hurthle cell tumours are associated with chromosomal abnormalities or mutations in the RAS gene, the PAX8/PPARG fusion gene, or the mitochondrial NADH-ubiquinone oxidoreductase 1a subcomplex-13 gene (NDUFA13; gene associated with retinoid- and interferon-induced mortality-19, GRIM19).

Subjects: Medicine and Health.


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