hybrid antibody

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An antibody generated experimentally by fusing hybridomas that produce two different antibodies; the hybrid cells produce three different antibodies, only one of which is a hybrid in the sense of having two different antigenic binding sites. Similar bispecific antibodies can be produced by the chemical reassociation of monovalent fragments derived from monoclonal mouse immunoglobulin G1. The term is sometimes also applied to antibodies covalently coupled to other molecules such as cytotoxic drugs. The ambiguity associated with the term means it should probably be avoided.

Subjects: Medicine and Health.

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