15-hydroxyprostaglandin dehydrogenase (NAD+)

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EC; an enzyme involved in the inactivation of prostaglandins E2, F, and B1, by oxidizing the 15‐hydroxyl group to a keto group. It catalyses a reaction between (5Z,13E)‐(15S)‐11α,15‐dihydroxy‐9‐oxoprost‐5,13‐dienoate and NAD+ to form (5Z,13E)‐11α‐hydroxy‐9,15‐dioxoprost‐5,13‐dienoate (15‐keto PGE2) and NADH.


Subjects: Chemistry.

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