A set of direct influences and feedback interactions between the hypothalamus, the pituitary gland and the adrenal glands. The HPA axis is a neuroendocrine system that is responsible for controlling stress reactions and the levels of cortisol and other stress-related hormones. The system is involved in mood disorders such as anxiety disorder, bipolar disorder, insomnia, post-traumatic stress disorder, ADHD, major depressive disorder, burnout, chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and alcoholism. Antidepressants are often used to regulate the responses.
Subjects: Medicine and Health.