The enzyme that catalyzes the transfer of the phosphoribosyl moiety of 5-phosphoribosyl-1-pyrophosphate to the 9 position of hypoxanthine and guanine to form inosine monophosphate and guanosine monophosphate. Abbreviated HPRT or HGPRT. The Lesch-Nyhan syndrome (q.v.) is caused by deficiency of HPRT. See Chronology, 1987, Kuehn et al.; HAT medium.
Subjects: Genetics and Genomics.