hypoxanthine-guanine-phosphoribosyl transferase

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The enzyme that catalyzes the transfer of the phosphoribosyl moiety of 5-phosphoribosyl-1-pyrophosphate to the 9 position of hypoxanthine and guanine to form inosine monophosphate and guanosine monophosphate. Abbreviated HPRT or HGPRT. The Lesch-Nyhan syndrome (q.v.) is caused by deficiency of HPRT. See Chronology, 1987, Kuehn et al.; HAT medium.

Subjects: Genetics and Genomics.

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