Overview

IcsA


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An actin nucleating protein present asymmetrically in the outer membrane of virulent strains of Shigella flexneri. An F-actin bundle (‘comet tail’) assembles at the pole with IcsA as a result of N-WASP activation and involvement of the Arp2/3 complex, and propels the bacterium through the cytoplasm.

Subjects: Medicine and Health.


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