A family of endogenous inhibitors of NFκB that bind to the p65 subunit and prevents relocation to the nucleus. Multiple forms have been identified including IκBα (317 aa) and IκBβ (356 aa). Phosphorylation of serine residues on the IκB proteins by IκB-kinases (IKK) targets them for destruction, thereby releasing the inhibition. X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by mutations in the gene encoding IKK-γ, the regulatory subunit of the kinase.
Subjects: Medicine and Health — Chemistry.