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'IκB' can also refer to...


IκB kinase

IκB kinase


The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer

Vitamin D decreases NFκB activity by increasing IκBα levels

Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury

Inflammation and postinfarct remodeling: Overexpression of IκB prevents ventricular dilation via increasing TIMP levels

Inhibition of Human Immunodeficiency Virus Type 1 Replication by Blocking IκB Kinase with Noraristeromycin

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

Oxidized phospholipids inhibit cyclooxygenase-2 in human macrophages via nuclear factor-κB/IκB- and ERK2-dependent mechanisms

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

Regulatory Peptides Modulate Adhesion of Polymorphonuclear Leukocytes to Bronchial Epithelial Cells through Regulation of Interleukins, ICAM-1 and NF-κB/IκB

Heterochromatin protein 1 gamma and IκB kinase alpha interdependence during tumour necrosis factor gene transcription elongation in activated macrophages

Cigarette smoke condensate activates nuclear transcription factor-κB through phosphorylation and degradation of IκBα: correlation with induction of cyclooxygenase-2

MEOX2 regulates nuclear factor-κB activity in vascular endothelial cells through interactions with p65 and IκBβ

IκBKβ and NFκB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases

Transcriptional and post-transcriptional regulation of IκB-ζ upon engagement of the BCR, TLRs and FcγR


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Quick Reference

A family of endogenous inhibitors of NFκB that bind to the p65 subunit and prevents relocation to the nucleus. Multiple forms have been identified including IκBα (317 aa) and IκBβ (356 aa). Phosphorylation of serine residues on the IκB proteins by IκB-kinases (IKK) targets them for destruction, thereby releasing the inhibition. X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by mutations in the gene encoding IKK-γ, the regulatory subunit of the kinase.

Subjects: Medicine and Health — Chemistry.

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