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Imd pathway


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One of two evolutionarily conserved defence mechanisms against infectious microorganisms, best defined in Drosophila, but not confined to insects. (The other pathway involves toll-like receptors.) The Imd pathway is usually activated by Gram-negative bacteria, and in turn activates the JNK signalling cascade and a NFκB transcription factor, Relish, which induces the expression of a set of genes that encode antimicrobial peptides.

Subjects: Medicine and Health.


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