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A motif (immunoreceptor tyrosine-based activation motif) in the cytoplasmic domain of immunoglobulin (Ig) superfamily molecules that becomes phosphorylated when the receptor binds ligand. When phosphorylated it can bind tyrosine kinases, such as zap-70 and syk, through tandem SH2 domains. Examples are found in T- and B-cell receptors, Fc receptors, NFAM1 (NFAT activating protein with ITAM motif-1) that regulates B-cell development and dectin-1 that is involved in dendritic cell function. Contrast with ITIMs.

Subjects: Medicine and Health — Chemistry.

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