immunoglobulin chains

'immunoglobulin chains' can also refer to...

immunoglobulin chains

immunoglobulin chains

A novel gene encoding goose immunoglobulin λ light chain

Immunoglobulin к Chain Locus on Chromosome 2p12 and Onchocerciasis

Evolution of immunoglobulin kappa chain variable region genes in vertebrates.

Clinical outcome of immunoglobulin light chain amyloidosis affecting the kidney

Classifying noisy protein sequence data: a case study of immunoglobulin light chains

Determining the roles of different chain fragments in recognition of immunoglobulin fold

The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement.

Coevolution of immunoglobulin heavy- and light-chain variable-region gene families.

Toward understanding the molecular pathogenesis of monoclonal immunoglobulin light-chain deposition

Analysis of the Immunoglobulin Light Chain Genes in Zebra Finch: Evolutionary Implications

Toward understanding the molecular pathogenesis of monoclonal immunoglobulin light-chain deposition

Molecular modeling of immunoglobulin light chains implicates hydrophobic residues in non-amyloid light chain deposition disease.

Kappa light chain-associated Fanconi's syndrome: molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals

Immunoglobulin gene polymerase chain reaction to distinguish hyperreactive malarial splenomegaly from ‘African’ chronic lymphocytic leukaemia and splenic lymphoma

Trial use of a polymethylmethacrylate membrane for the removal of free immunoglobulin light chains in dialysis patients

Design and construction of a hybrid immunoglobulin domain with properties of both heavy and light chain variable regions.

Absolute conservation of residue 6 of immunoglobulin heavy chain variable regions of class IIA is required for correct folding.


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The components of the heteropolymeric immunoglobulin molecules. There are five groups of heavy chains, each characteristic of a specific class of immunoglobulin: gamma (IgG), mu (IgM), epsilon (IgE), alpha (IgA), and delta (IgD). The genes encoding all the heavy immunoglobulin chains are located on human chromosome 14. The constant region of each heavy chain makes up about three-fourths of the molecule, and the gene segments encoding the constant regions are arranged in the sequence mu, delta, gamma, epsilon, and alpha in both humans and mice. There are two groups of light chains: kappa chains, encoded by gene segments on human chromosome 2, and lambda chains, encoded by gene segments on chromosome 22. See immunoglobulin genes.

Subjects: Genetics and Genomics.

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