Overview

immunophilin


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Intracellular proteins that bind immunosuppressive drugs such as ciclosporin, tacrolimus, and rapamycin. Both cyclophilin and the receptor for tacrolimus (FK binding proteins; FKBPs; 100–1219 aa) are peptidyl prolyl cis-trans isomerases (rotamases) although their enzymic activity seems irrelevant to the binding activity. Immunophilins are thought to interact with calcineurin.

Subjects: Chemistry — Medicine and Health.


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